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  • JAMA Pediatrics July 1, 2017

    Figure: Abrupt Onset of Pustules in a Child

    A, Right arm with erythematous edematous plaque with superimposed pinpoint pustules and associated superficial desquamation. B, Bilateral buttocks with well-demarcated, erythematous plaques with pustules at the periphery. Superficial desquamation is present at the superior aspect of the buttocks. C, Hematoxylin-eosin stain (original magnification × 20).
  • JAMA Pediatrics July 1, 2017

    Figure: Tissue Localization and Cellular Response to Gadolinium Deposition

    Cellular localization of gadolinium using transmission electron microscopy (TEM) on tissue samples stained with 0.2% lead citrate are shown for the dentate nuclei of control patient 1 (A) and gadodiamide-exposed patient 3 (B) at 10 000-fold magnification. X-ray spectra of a selected electron dense foci (black arrowheads) are shown in the inset of each respective panel on a selected electron dense foci; gadolinium peaks in the spectra are indicated by red color overlay. Light microscopy images of hematoxylin-eosin–stained dentate nuclei samples (original magnification × 100) are shown for control patient 1 (C) and gadodiamide-exposed patients 3 and 1 (D and E). F, Neurofilament-immunostained dentate nuclei samples (original magnification × 200) for gadodiamide-exposed patient 1. Arrowheads indicate axonal spheroids. C indicates carbon; ca, calcium; gd, gadolinium; ni, nickel; o; oxygen; and pb, lead.
  • JAMA Pediatrics September 1, 2016

    Figure 2: Newborn With a Diffuse Rash

    Histopathologic image, hematoxylin-eosin, magnification x400. The atypical histiocytes have grooves and folds, occasionally producing a reniform appearance. B, Immunohistochemical stain for CD1a, magnification x40.
  • JAMA Pediatrics August 1, 2016

    Figure: 7-Year-Old With a Painful Rash

    A, Painful raised circular violaceous papulonecrotic lesion with surrounding erythema on child’s right upper arm. B, Punch biopsy of lesion. Hematoxylin-eosin stain reveals dense neutrophilic infiltrate in the dermis as well as papillary dermal edema (original magnification × 40).
  • JAMA Pediatrics December 1, 2015

    Figure: A Crusted Papule in a Premature Neonate

    A, Crusted circular papule with a surrounding rim of erythema and induration on the left hip. B, Biopsy specimen revealing epidermal necrosis with fungal elements within the superficial dermis (hematoxylin-eosin, original magnification ×20). C, Biopsy specimen highlighting branching and septate hyphae within the superficial dermis (specimen was stained with Gomori methenamine silver, original magnification ×40).
  • JAMA Pediatrics August 1, 2015

    Figure 2: Infant With a Unilateral Parotid Mass, Recurrent Otitis Media, and Macrocephaly

    Plexiform neurofibroma. Large fascicles of spindle cells are embedded in a myxoid stroma. Salivary glands are present at the periphery (hematoxylin-eosin, original magnification ×100).
  • JAMA Pediatrics May 1, 2015

    Figure 2: Follicular Rash on the Knees and Hyperkeratotic Palms: A Difficult Diagnosis

    Results of histologic examination revealed alternating vertical and horizontal orthokeratosis (white arrowheads) and parakeratosis (blue arrowheads) in a checkerboard pattern (hematoxylin-eosin, original magnification x40).
  • JAMA Pediatrics October 1, 2014

    Figure: Grouped Hemorrhagic Vesicles

    Translucent papules and histologic examination in a child. A, Clinical examination shows numerous grouped translucent papules. B and C, Dilated thin-walled vascular spaces containing valvelike papillary projections in the superficial dermis. The overlying epidermis shows acanthosis and hyperkeratosis (hematoxylin-eosin, original magnification ×20 [B] and ×400 [C]).
  • JAMA Pediatrics August 1, 2014

    Figure: An 18-Year-Old Man With Bilateral Violaceous Cervical Adenopathy

    A, Bilateral level IV (low jugular) cervical adenopathy. B, Chest radiograph showing bilateral hilar adenopathy. C, Histological examination of the excised lymph node showing multiple spherules containing endospores (arrowheads) (hematoxylin-eosin, original magnification ×200).
  • JAMA Pediatrics May 1, 2014

    Figure 2: Boy With Yellow-Orange, Rough Nodule on Right Thigh

    A, Hematoxylin-eosin stain demonstrating dermal, thin-walled vessels with flat endothelium. B, Histopathology with D2-40 staining, which stains positive in the presence of lymphatic endothelium. Original magnifications ×10.
  • JAMA Pediatrics March 1, 2014

    Figure 2: Rare Adverse Effect of Treatment With Minocycline

    Medium-sized vessel with neutrophilic vasculitis (hematoxylin-eosin, original magnification ×100).
  • JAMA Pediatrics August 1, 2013

    Figure: Fever and Rash in a 7-Month-Old Infant

    Clinical and histologic images of papulovesicles. The clinical images show scattered pink papulovesicles, some with overlying hemorrhagic crust (A and B). C, A histologic section (hematoxylin and eosin, original magnification ×10) of a papule shows a focally eroded epidermis (asterisk) with a relatively dense and diffuse perivascular and interstitial dermal infiltrate (arrow) of predominantly mononuclear cells and a few neutrophils, with changes indicative of a mild vasculitis.
  • JAMA Pediatrics January 1, 2013

    Figure: Picture of the Month—Quiz Case

    Figure 2. Scanning view of the biopsy specimen, showing a well-defined dermal proliferation of large polyhedral cells (hematoxylin-eosin, original magnification ×20).
  • JAMA Pediatrics January 1, 2013

    Figure: Picture of the Month—Diagnosis

    Figure 2. Scanning view of the biopsy specimen, showing a well-defined dermal proliferation of large polyhedral cells (hematoxylin-eosin, original magnification ×20).
  • JAMA Pediatrics January 1, 2013

    Figure: Picture of the Month—Quiz Case

    Figure 3. Close-up of the cells shows abundant eosinophilic granular cytoplasm and centrally located vesicular nuclei. The cells were arranged in cords and surrounded by a dense collagenous stroma. No significant cellular atypia or degenerative changes were seen (hematoxylin-eosin, original magnification ×200).
  • JAMA Pediatrics January 1, 2013

    Figure: Picture of the Month—Diagnosis

    Figure 3. Close-up of the cells shows abundant eosinophilic granular cytoplasm and centrally located vesicular nuclei. The cells were arranged in cords and surrounded by a dense collagenous stroma. No significant cellular atypia or degenerative changes were seen (hematoxylin-eosin, original magnification ×200).
  • Picture of the Month—Quiz Case

    Abstract Full Text
    free access
    JAMA Pediatr. 2013; 167(1):85-85. doi: 10.1001/2013.jamapediatrics.209a
  • JAMA Pediatrics June 1, 2011

    Figure 2: Picture of the Month—Diagnosis

    Skin biopsy specimen showing septal and lobular inflammatory infiltrate of lymphocytes (green arrowhead), plasma cells, histiocytes (blue arrowhead), and a few eosinophils (black arrowhead) wedged in between the fat cells in subcutaneous fat. Fat cells contain fine, eosinophilic cytoplasmic strands forming clefts (arrow) (hematoxylin-eosin, original magnification ×40).
  • JAMA Pediatrics October 1, 2010

    Figure 3: Picture of the Month—Diagnosis

    Cross-section of the patient's Echinococcus granulosuspulmonary cyst. The thin nucleated inner cyst layer produces protoscolices. Four calcified scolices, indicative of an aged cyst, are visible along the edge of the cyst wall. The cyst wall is composed of an acellular laminated external layer (horizontal arrow) and a thin, germinal (nucleated) inner layer (vertical arrow) (stained with hematoxylin-eosin, original magnifiation ×40).
  • JAMA Pediatrics April 6, 2009

    Figure 2: Picture of the Month—Quiz Case

    Inverted lobules of acanthotic squamous epithelium (arrow) with eosinophilic bodies in the upper epidermis (hematoxylin-eosin, original magnification ×40).