http://archpedi.jamanetwork.com/ en-us Mon, 10 Dec 2012 00:00:00 GMT Tue, 01 Jan 2013 00:49:45 GMT Silverchair editor@archpedi.jamanetwork.com webmaster@archpedi.jamanetwork.com http://archpedi.jamanetwork.com/article.aspx?articleID=1216494 Sat, 01 Sep 2012 00:00:00 GMT Jack SJ, Ou K, Chea M, et al. <span class="paragraphSection"><div class="boxTitle">Objective</div>To evaluate the effectiveness of Sprinkles alongside infant and young child feeding (IYCF) education compared with IYCF education alone on anemia, deficiencies in iron, vitamin A, and zinc, and growth in Cambodian infants.<div class="boxTitle">Design</div>Cluster-randomized effectiveness study.<div class="boxTitle">Setting</div>Cambodian rural health district.<div class="boxTitle">Participants</div>Among 3112 infants aged 6 months, a random subsample (n = 1350) was surveyed at baseline and 6-month intervals to age 24 months.<div class="boxTitle">Intervention</div>Daily micronutrient Sprinkles alongside IYCF education vs IYCF education alone for 6 months from ages 6 to 11 months.<div class="boxTitle">Main Outcome Measures</div>Prevalence of anemia; iron, vitamin A, and zinc deficiencies; and growth via biomarkers and anthropometry.<div class="boxTitle">Results</div>Anemia prevalence (hemoglobin level <11.0 g/dL [to convert to grams per liter, multiply by 10.0]) was reduced in the intervention arm compared with the control arm by 20.6% at 12 months (95% CI, 9.4-30.2; P = .001), and the prevalence of moderate anemia (hemoglobin level <10.0 g/dL) was reduced by 27.1% (95% CI, 21.0-31.8; P < .001). At 12 and 18 months, iron deficiency prevalence was reduced by 23.5% (95% CI, 15.6-29.1; P < .001) and 11.6% (95% CI, 2.6-17.9; P = .02), respectively. The mean serum zinc concentration was increased at 12 months (2.88 μg/dL [to convert to micromoles per liter, multiply by 0.153]; 95% CI, 0.26-5.42; P = .03). There was no statistically significant difference in the prevalence of zinc and vitamin A deficiencies or in growth at any time.<div class="boxTitle">Conclusions</div>Sprinkles reduced anemia and iron deficiency and increased the mean serum zinc concentration in Cambodian infants. Anemia and zinc effects did not persist beyond the intervention period.<div class="boxTitle">Trial Registration</div>anzctr.org.au Identifier: ACTRN12608000069358</span> 166 9 842 850 10.1001/archpediatrics.2012.1003 http://archpedi.jamanetwork.com/article.aspx?articleID=1216494 http://archpedi.jamanetwork.com/article.aspx?articleID=1356481 Sat, 01 Sep 2012 00:00:00 GMT Zlotkin S. <span class="paragraphSection">Most trials examining the impact of micronutrient powders on anemia and iron status have been efficacy studies where variables were controlled and the interventions were closely supervised. A meta-analysis of efficacy trials demonstrated that Sprinkles, a micronutrient powder, were as effective as iron drops and had fewer adverse effects. In the prevention trials, the risk for anemia was cut in half.</span> 166 9 869 870 10.1001/archpediatrics.20112.1514 http://archpedi.jamanetwork.com/article.aspx?articleID=1356481