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Basic View | Expanded View
 Showing 21-37 of 37 Articles
On My Mind 
Abby R. Rosenberg, MD, MS
We see it in the media after natural disasters or school shootings: communities come together after tragedy. And we watch from the outside, perhaps with a bit of guilt-tinged relief or gratitude that it didn’t happen to us.
Neil Marlow, DM, FMedSci
Neonatal intensive care has been one of the success stories of the past 30 years, with steadily improving survival and slowly improving long-term outcomes for infants born early. In the 1980s, few infants born at 25 through 26 weeks of gestation survived, but now high survival and low morbidity rates ...
Original Investigation 
Johanna Bick, PhD; Tong Zhu, PhD; Catherine Stamoulis, PhD; Nathan A. Fox, PhD; Charles Zeanah, MD; Charles A. Nelson, PhD
Includes: Supplemental Content

Importance  Severe neglect in early life is associated with compromises in brain development and associated behavioral functioning. Although early intervention has been shown to support more normative trajectories of brain development, specific improvements in the white matter pathways that underlie emotional and cognitive development are unknown.


Original Investigation 
Pierre-Yves Ancel, PhD; François Goffinet, PhD; and the EPIPAGE-2 Writing Group
Includes: Supplemental Content

Importance  Up-to-date estimates of the health outcomes of preterm children are needed for assessing perinatal care, informing parents, making decisions about care, and providing evidence for clinical guidelines.

Objectives  To determine survival and neonatal morbidity of infants born from 22 through 34 completed weeks’ gestation in ...

Editorial: Outcomes for Low Gestational Age Infants; Neil Marlow, DM, FMedSci
Edward L. Schor, MD
This Viewpoint reports on the recent attention to “millennial morbidities,” those chronic and sometimes intractable medical problems, such as obesity, type 2 diabetes, and family violence, that originate at the interface between biological, psychological, social, and environmental dimensions.
Original Investigation 
Brian K. Kit, MD, MPH; Elena Kuklina, MD; Margaret D. Carroll, MSPH; Yechiam Ostchega, PhD, RN; David S. Freedman, PhD; Cynthia L. Ogden, PhD

Importance  Recent national data suggest there were improvements in serum lipid concentrations among US children and adolescents between 1988 and 2010 but an increase in or stable blood pressure (BP) during a similar period.

Objective  To describe the prevalence of and trends in dyslipidemia and adverse ...

Original Investigation 
Susanne E. Tanski, MD, MPH; Auden C. McClure, MD, MPH; Zhigang Li, PhD; Kristina Jackson, PhD; Matthis Morgenstern, PhD; Zhongze Li, MS; James D. Sargent, MD
Includes: Supplemental Content

Importance  Alcohol is the most common drug among youth and a major contributor to morbidity and mortality worldwide. Billions of dollars are spent annually marketing alcohol.

Objective  To examine the reach of television alcohol advertising and its effect on drinking among underage youth.

Design, Setting, and ...

Research Letter 
Stefano Bembich, PhD; Gabriele Cont, MD; Giulio Baldassi, BS; Jenny Bua, MD; Sergio Demarini, MD
Nonpharmacologic analgesia is administered in newborns using, for example, sweet solutions, breastfeeding, or maternal holding.1,2 Nonpharmacologic analgesia can decrease pain during minor procedures, such as a heel prick for blood sampling. From a neurophysiological standpoint, a previous study1 has demonstrated that, during a heel prick, oral glucose administration is associated ...
Aaron E. Carroll, MD, MS
A recent study conducted by the RAND Corporation investigated factors that most influence physician satisfaction.1 Many physicians I know expected the findings to include the usual complaints one might see in opinion editorials and press releases from major professional organizations, such as “falling Medicare reimbursement,” “increased regulations,” or “malpractice reform.” ...
Tuberculosis is a major unrecognized cause of disease and death in young children living in tuberculosis-endemic settings.1 Recent estimates suggest that nearly a million children develop tuberculosis each year, although accurate quantification of the tuberculosis disease burden in children is hampered by difficulties in establishing an accurate diagnosis.2,3 Tuberculosis case ...
Original Investigation 
Jonathan M. Ellen, MD; Lauren Greenberg, MPH; Nancy Willard, MS; James Korelitz, PhD; Bill G. Kapogiannis, MD; Dina Monte, BSN; Cherrie B. Boyer, PhD; Gary W. Harper, PhD; Lisa M. Henry-Reid, MD; Lawrence B. Friedman, MD; René Gonin, PhD
Includes: Supplemental Content

Importance  With the emphasis on structural-level interventions that target social determinants of human immunodeficiency virus (HIV) transmission to curb the HIV epidemic, there is a need to develop evaluation models that can detect changes in individual factors associated with HIV-related structural changes.

Objective  To describe whether ...

Original Investigation 
M. Elsa Villarino, MD, MPH; Nigel A. Scott, MS; Stephen E. Weis, DO; Marc Weiner, MD; Marcus B. Conde, MD; Brenda Jones, MD; Sharon Nachman, MD; Ricardo Oliveira, MD; Ruth N. Moro, MD, MPH; Nong Shang, PhD; Stefan V. Goldberg, MD; Timothy R. Sterling, MD; for the International Maternal Pediatric and Adolescents AIDS Clinical Trials Group (IMPAACT) and the Tuberculosis Trials Consortium (TBTC)
Includes: Supplemental Content

Importance  Three months of a once-weekly combination of rifapentine and isoniazid for treatment of latent tuberculosis infection is safe and effective for persons 12 years or older. Published data for children are limited.

Objectives  To compare treatment safety and assess noninferiority treatment effectiveness of combination therapy ...

Editorial: Twelve-Dose Drug Regimen for Tuberculosis; Ben J. Marais, PhD
Geert W. ‘t Jong, MD, PhD; Terry P. Klassen, MD, MSc, FRCPC; Stuart M. MacLeod, BSc(Med), MD, PhD, FRCPC
This Viewpoint discusses the publication of the Council of Canadian Academies report “Improving Medicines for Children in Canada.”
Original Investigation 
Yvonne W. Wu, MD, MPH; Michael W. Kuzniewicz, MD, MPH; Andrea C. Wickremasinghe, MD; Eileen M. Walsh, RN, MPH; Soora Wi, MPH; Charles E. McCulloch, PhD; Thomas B. Newman, MD, MPH
Includes: Supplemental Content, Multimedia: (powerpoint)

Importance  Exchange transfusion is recommended for newborns with total serum bilirubin (TSB) levels thought to place them at risk for cerebral palsy (CP). However, the excess risk for CP among these infants is unknown.

Objective  To quantify the risks for CP and CP consistent with kernicterus ...

Original Investigation 
Fernando C. Barros, MD; Aris T. Papageorghiou, MD; Cesar G. Victora, MD; Julia A. Noble, DPhil; Ruyan Pang, MD; Jay Iams, MD; Leila Cheikh Ismail, PhD; Robert L. Goldenberg, MD; Ann Lambert, PhD; Michael S. Kramer, MD; Maria Carvalho, MD; Agustin Conde-Agudelo, MD; Yasmin A. Jaffer, MD; Enrico Bertino, MD; Michael G. Gravett, MD; Doug G. Altman, DSc; Eric O. Ohuma, MSc; Manorama Purwar, MD; Ihunnaya O. Frederick, PhD; Zulfiqar A. Bhutta, PhD; Stephen H. Kennedy, MD; José Villar, MD; for the International Fetal and Newborn Growth Consortium for the 21st Century (INTERGROWTH-21st)
Includes: Supplemental Content

Importance  Preterm birth has been difficult to study and prevent because of its complex syndromic nature.

Objective  To identify phenotypes of preterm delivery syndrome in the Newborn Cross-Sectional Study of the INTERGROWTH-21st Project.

Design, Setting, and Participants  A population-based, multiethnic, cross-sectional study conducted at 8 ...

Annual Reviewers List  FREE
Frederick P. Rivara, MD, MPH
“You mean you do that for free? Why would you spend the time? What's in it for you?”
Alain Joffe, MD, MPH; Frederick P. Rivara, MD, MPH
How best to transition adolescents and young adults—particularly medically complex individuals or those with a chronic illness or disability—from a pediatric to an adult system of health care remains a largely unanswered question. Challenges to a smooth transition include being able to identify those most in need of transition planning, ...

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