TY  - JOUR
T1  - EFfect of honey, dextromethorphan, and no treatment on nocturnal cough and sleep quality for coughing children and their parents
AU  - Paul IM, Beiler J, McMonagle A, Shaffer ML, Duda L, Berlin CM, Jr
Y1  - 2007/12/01
N1  - 10.1001/archpedi.161.12.1140
JO  - Archives of Pediatrics & Adolescent Medicine
SP  - 1140
EP  - 1146
VL  - 161
IS  - 12
N2  - Objectives 
    To compare the effects of a single nocturnal dose of buckwheat honey or honey-flavored dextromethorphan (DM) with no treatment on nocturnal cough and sleep difficulty associated with childhood upper respiratory tract infections.Design 
    A survey was administered to parents on 2 consecutive days, first on the day of presentation when no medication had been given the prior evening and then the next day when honey, honey-flavored DM, or no treatment had been given prior to bedtime according to a partially double-blinded randomization scheme.Setting 
    A single, outpatient, general pediatric practice.Participants 
    One hundred five children aged 2 to 18 years with upper respiratory tract infections, nocturnal symptoms, and illness duration of 7 days or less.Intervention 
    A single dose of buckwheat honey, honey-flavored DM, or no treatment administered 30 minutes prior to bedtime.Main Outcome Measures 
    Cough frequency, cough severity, bothersome nature of cough, and child and parent sleep quality.Results 
    Significant differences in symptom improvement were detected between treatment groups, with honey consistently scoring the best and no treatment scoring the worst. In paired comparisons, honey was significantly superior to no treatment for cough frequency and the combined score, but DM was not better than no treatment for any outcome. Comparison of honey with DM revealed no significant differences.Conclusions 
    In a comparison of honey, DM, and no treatment, parents rated honey most favorably for symptomatic relief of their child's nocturnal cough and sleep difficulty due to upper respiratory tract infection. Honey may be a preferable treatment for the cough and sleep difficulty associated with childhood upper respiratory tract infection.Trial Registration 
    clinicaltrials.gov Identifier
SN  - 1072-4710
M3  - doi: 10.1001/archpedi.161.12.1140
UR  - http://dx.doi.org/10.1001/archpedi.161.12.1140
ER  -