TY  - JOUR
T1  - CArdiac malformations in relatives of infants with hypoplastic left-heart syndrome
AU  - Brenner JI, Berg KA, Schneider DS, Clark EB, Boughman JA
Y1  - 1989/12/01
N1  - 10.1001/archpedi.1989.02150240114030
JO  - American Journal of Diseases of Children
SP  - 1492
EP  - 1494
VL  - 143
IS  - 12
N2  - • In a pilot study of relatives of infants with hypoplastic left-heart syndrome (HLHS), we obtained a medical history, cardiovascular examination, and echocardiogram in 48 first-degree relatives of 11 probands with isolated HLHS and 3 with HLHS and noncardiac malformations. Echocardiography confirmed heart defects in 5 of 41 relatives of patients with isolated HLHS. In four instances, the cardiac abnormality was unrecognized. Among 7 relatives of infants with HLHS and extracardiac anomalies, no heart defects were detected. Cardiac defects occurred in first-degree relatives of probands at a frequency higher than previously predicted by an additive multifactorial model of inheritance. These findings suggest that first-degree relatives of HLHS probands may have an increased risk for subclinical cardiac defects and that genetic factors likely contribute to the cause of left-heart blood-flow lesions.(AJDC. 1989;143:1492-1494)
SN  - 0002-922X
M3  - doi: 10.1001/archpedi.1989.02150240114030
UR  - http://dx.doi.org/10.1001/archpedi.1989.02150240114030
ER  -