TY  - JOUR
T1  - NEonatal hyperbilirubinemia at high altitude
AU  - Leibson C, Brown M, Thibodeau S, et al
Y1  - 1989/08/01
N1  - 10.1001/archpedi.1989.02150200145036
JO  - American Journal of Diseases of Children
SP  - 983
EP  - 987
VL  - 143
IS  - 8
N2  - • A previous retrospective study showed an increased frequency of neonatal hyperbilirubinemia at high altitude in Colorado. In a prospective study we found that 39% of newborns at 3100m altitude vs 16% at 1600 m exhibited hyperbilirubinemia, defined as a day 3 serum bilirubin level of 205 μmol/L or higher. Increased bilirubin production at 3100 m vs 1600 m was shown by increased levels of corrected carboxyhemoglobin. This finding was supported by increased erythropoietin and bilirubin values in cord blood and increased hematocrit values at day 3 among infants at 3100 m vs 1600 m. The sustained elevation in bilirubin for breastfed vs formula-fed infants at 1600 m was observed for both feeding types at 3100 m. The findings suggested that there is a hematologic response to decreased oxygen availability at high altitude, resulting in increased bilirubin production accompanied by delayed bilirubin clearance.(AJDC. 1989;143:983-987)
SN  - 0002-922X
M3  - doi: 10.1001/archpedi.1989.02150200145036
UR  - http://dx.doi.org/10.1001/archpedi.1989.02150200145036
ER  -