TY  - JOUR
T1  - INsulinlike growth factors in patients with active nephrotic syndrome
AU  - Garin EH, Grant MB, Silverstein JH
Y1  - 1989/07/01
N1  - 10.1001/archpedi.1989.02150190115035
JO  - American Journal of Diseases of Children
SP  - 865
EP  - 867
VL  - 143
IS  - 7
N2  - • The serum concentrations of insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) were measured by specific radioimmunoassays in 25 nephrotic patients. The serum concentration of IGF-1 in nephrotic patients (mean±SEM, 169±17 ng/mL) was significantly lower than that observed in 20 control subjects matched for sex and age (338±36 ng/mL). The IGF-2 serum concentration was significantly lower in nephrotic patients (343 ±22 ng/mL) than in control subjects (898±80 ng/mL). The IGF-1 and IGF-2 150-kd and 45-kd carrier protein complexes were found in the urine of nephrotic patients, whereas there was no binding of radiolabeled IGF-1 or IGF-2 to IGF carrier proteins in the urine of control subjects. The low serum IGF-1 and IGF-2 levels observed in nephrotic patients could be partially due to the increased urinary losses of the IGF carrier proteins.(AJDC. 1989;143:865-867)
SN  - 0002-922X
M3  - doi: 10.1001/archpedi.1989.02150190115035
UR  - http://dx.doi.org/10.1001/archpedi.1989.02150190115035
ER  -