TY  - JOUR
T1  - THe diagnosis of neurofibromatosis-1 in the child under the age of 6 years
AU  - Obringer AC, Meadows AT, Zackai EH
Y1  - 1989/06/01
N1  - 10.1001/archpedi.1989.02150180099028
JO  - American Journal of Diseases of Children
SP  - 717
EP  - 719
VL  - 143
IS  - 6
N2  - • One-hundred sixty children under the age of 6 years presented for diagnostic evaluation regarding neurofibromatosis-1 (NF-1). Using the National Institutes of Health Consensus Conference criteria, 151 (94%) of the children were classified on initial examination: 112 were diagnosed as having NF-1 and 39 were found to be unaffected (all 39 have remained asymptomatic on follow-up). Nine could not be classified (3 have subsequently met minimal diagnostic criteria on followup). Clinical manifestations of NF-1 include cafe au lait spots (97%), freckling in the axillary or inguinal region (81%), Lisch nodules (30%), neurofibromas (15%), pseudoarthrosis (6%), and optic nerve gliomas (4%). More than minimal diagnostic criteria were met by 80% of the children who had a positive family history and by 32% of those who did not. Thus, the clinical diagnosis of NF-1 is possible in the child who is under 6 years of age, and the National Institutes of Health criteria are useful and applicable.(AJDC. 1989;143:717-719)
SN  - 0002-922X
M3  - doi: 10.1001/archpedi.1989.02150180099028
UR  - http://dx.doi.org/10.1001/archpedi.1989.02150180099028
ER  -