TY  - JOUR
T1  - DOes methylprednisolone pulse therapy deteriorate the course of rapidly progressive iga nephropathy?-reply
AU  - WELCH TR, McADAMS A, BERRY A
Y1  - 1989/04/01
N1  - 10.1001/archpedi.1989.02150160064008
JO  - American Journal of Diseases of Children
SP  - 442
EP  - 442
VL  - 143
IS  - 4
N2  - In Reply.—The case reported by Itami et al is consistent with our belief that MPT does not improve the course of rapidly progressive IgA nephropathy. As we stated in our article, such therapy was attempted in three of the five patients with no discernible benefit. The rationale for using the therapy in these patients had been our apparent success in using MPT for the treatment of some patients with idiopathic RPGN.1 In retrospect, it is obvious to us that this approach is of no use in rapidly progressive IgA nephropathy or in any other crescentic immune complex glomerulonephritis. Whether such therapy can actually hasten the deterioration in renal function is not clear. With a creatinine clearance of 27.5 mL/min/1.73 m2 and a biopsy specimen showing globally sclerotic glomeruli, it would seem that the renal function of the patient of Itami et al was destined to deteriorate whether or not
SN  - 0002-922X
M3  - doi: 10.1001/archpedi.1989.02150160064008
UR  - http://dx.doi.org/10.1001/archpedi.1989.02150160064008
ER  -