TY  - JOUR
T1  - PIcture of the month
AU  - Gellis SS, Feingold M, Char F
Y1  - 1979/11/01
N1  - 10.1001/archpedi.1979.02130110097020
JO  - American Journal of Diseases of Children
SP  - 1189
EP  - 1190
VL  - 133
IS  - 11
N2  - Denouement and Discussion 
    Aminopterin Embryopathy Syndrome 
    Manifestations 
    Aminopterin, a folic acid antagonist, has been used to induce abortions during the first trimester of pregnancy. Fetuses who survive this means of attempted abortion have a consistent pattern of malformations. These include prenatal and postnatal growth deficiency, lack of ossification of various cranial bones, delayed fontanel closure, lambdoid and coronal suture synostosis, upswept frontal hair pattern, broad nasal bridge, ocular hypertelorism, shallow supraorbital ridges, prominent eyes, micrognathia, cleft palate, and low-set posteriorly rotated ears. Skeletal defects consist of short forearms, hand abnormalities, congenital hip dislocation, and talipes equinovarus. Occasionally, cardiac and renal abnormalities occur. Intellectual function usually ranges from normal to mild retardation.Treatment 
    The various birth defects should be surgically repaired whenever possible. Special schooling is frequently helpful.
SN  - 0002-922X
M3  - doi: 10.1001/archpedi.1979.02130110097020
UR  - http://dx.doi.org/10.1001/archpedi.1979.02130110097020
ER  -