TY  - JOUR
T1  - PYridoxine-dependent seizures requiring high doses of pyridoxine for control
AU  - CLARKE TA, SAUNDERS BS, FELDMAN B, Scholl ML
Y1  - 1979/09/01
N1  - 10.1001/archpedi.1979.02130090091021
JO  - American Journal of Diseases of Children
SP  - 963
EP  - 965
VL  - 133
IS  - 9
N2  - Pyridoxine (or vitamin B6) dependency is a rare but well-recognized cause of neonatal seizures and, if not treated early, may lead to irreversible mental retardation. The diagnosis depends on the control of clinical and electrical seizure activity by pyridoxine hydrochloride. Previous reports have shown clinical control of seizures in seconds to minutes and EEG control in minutes to days.1.2 Because of the rarity of pyridoxine dependency as a cause of neonatal seizures, the lack of a specific laboratory diagnostic test, and the inexactness of the literature concerning EEG response to therapy, the clinician may overlook this disease. We recently cared for an infant who had focal neonatal seizures that responded to unusually high doses of pyridoxine.Report of a Case.—A 3.0-kg male was lelivered at term by elective cesarean section for double-footling presentation to a 22-year-old gravida 3, para 1, abortus 1 mother. The Apgar score was
SN  - 0002-922X
M3  - doi: 10.1001/archpedi.1979.02130090091021
UR  - http://dx.doi.org/10.1001/archpedi.1979.02130090091021
ER  -