TY  - JOUR
T1  - RBc surface pits in the sickle hemoglobinopathies
AU  - Sills RH, Oski FA
Y1  - 1979/05/01
N1  - 10.1001/archpedi.1979.02130050070014
JO  - American Journal of Diseases of Children
SP  - 526
EP  - 527
VL  - 133
IS  - 5
N2  - • Functional asplenia develops in children with sickle cell anemia. This asplenia is related to the increased incidence of bacterial sepsis that has been documented in these patients. With the use of direct-interference contrast microscopy to quantitate splenic function, we studied children with the sickle hemoglobinopathies. A gradual increase in splenic dysfunction with increasing age was documented in children with homozygous sickle cell disease. Children with the sickle variants also seem to manifest degrees of splenic dysfunction. Direct-interference contrast microscopy is a simple quantitative technique for the evaluation of splenic function in children with the sickle hemoglobinopathies.(Am J Dis Child 133:526-527, 1979)
SN  - 0002-922X
M3  - doi: 10.1001/archpedi.1979.02130050070014
UR  - http://dx.doi.org/10.1001/archpedi.1979.02130050070014
ER  -