TY  - JOUR
T1  - GErm cells and ova in dysgenetic gonads of a 46-xy female dizygotic twin
AU  - Cussen LJ, MacMahon RA
Y1  - 1979/04/01
N1  - 10.1001/archpedi.1979.02130040027005
JO  - American Journal of Diseases of Children
SP  - 373
EP  - 375
VL  - 133
IS  - 4
N2  - • The frequency of germ cell neoplasms in girls with 46-XY gonadal dysgenesis suggests that germ cells may persist in the dysgenetic gonads for many years. A phenotypic female infant with a karyotype of 46-XY in blood, skin, and gonads had a few ova in primordial follicles and numerous germ cells in her dysgenetic gonads at the age of 3 months. At 3 years and 10 months of age her gonads contained no primordial follicle and the only remaining germ cells were in a gonadoblastoma. We propose that germ cells are lost from dysgenetic gonads much more rapidly than from normal gonads, but that the rate of loss in patients with a karyotype of 46-XY may be less than the rate of loss in patients with a karyotype of 45-XO.(Am J Dis Child 133:373-375, 1979)
SN  - 0002-922X
M3  - doi: 10.1001/archpedi.1979.02130040027005
UR  - http://dx.doi.org/10.1001/archpedi.1979.02130040027005
ER  -