TY  - JOUR
T1  - STudies of 16-androstenes in an infant with virilizing adrenal carcinoma
AU  - Gregory T, Gardner LI, Gower DB, Bicknell DC, Barlow MJ
Y1  - 1979/03/01
N1  - 10.1001/archpedi.1979.02130030070012
JO  - American Journal of Diseases of Children
SP  - 294
EP  - 297
VL  - 133
IS  - 3
N2  - • An 18-month-old girl with virilization was found to have an encapsulated right adrenal carcinoma (2 × 3 cm) with great variation in nuclear size, frequent mitoses, and possible blood vessel invasion. Preoperative urinary excretions of 17-ketosteroids, androsterone, etiocholanolone, dehydroepiandrosterone, testosterone, pregnanetriol, 3α-androstenol, and 3β-androstadienol were elevated; all showed a noticeable decrease postoperatively. Cortisol acetate, given preoperatively, produced a definite decrease in the urinary excretion of 17-ketosteroids and dehydroepiandrosterone; administration of corticotropin resulted in an increase in levels of urinary 17-ketosteroids, 17-hydroxycorticosteroids, and pregnanetriol. Urinary testosterone and 3β-androstadienol may have diagnostic value since neither was suppressed by cortisol therapy. The behavior of both 3α-androstenol and 3β-androstadienol in this study suggests that they are of adrenal origin.(Am J Dis Child 133:294-297, 1979)
SN  - 0002-922X
M3  - doi: 10.1001/archpedi.1979.02130030070012
UR  - http://dx.doi.org/10.1001/archpedi.1979.02130030070012
ER  -