TY  - JOUR
T1  - Neurobiology: Mind and matter
AU  - McKhann GM
Y1  - 1969/12/01
N1  - 10.1001/archpedi.1969.02100040832005
JO  - American Journal of Diseases of Children
SP  - 830
EP  - 835
VL  - 118
IS  - 6
N2  - IN THIS discussion I have chosen to sample the burgeoning field of neurobiology in an attempt to relate this field to clinical problems of the developing nervous system. Before doing that, I shall consider some of the present concepts about the nervous system, and question whether they will hold up over the coming years.One of the questions concerns the concept that the development of the nervous system is a carefully programmed event, with little room for variation and little flexibility. I should like to question this concept in terms of the criteria listed below:Stages of Neuronal DevelopmentNeuronal formation First trimesterNeuronal migration Second trimesterNeuronal interconnection Third trimester and PostnatalMyelin formation PostnatalNeuronal Formation 
    There is considerable evidence that the concept of a specific time for neuronal formation is too rigid. On the contrary, there are neurons which continue to form during fetal development, and, in
SN  - 0002-922X
M3  - doi: 10.1001/archpedi.1969.02100040832005
UR  - http://dx.doi.org/10.1001/archpedi.1969.02100040832005
ER  -