TY  - JOUR
T1  - MAssive spasms associated with holoprosencephaly
AU  - Schimschock JR, Carlson CB, Ojemann LM
Y1  - 1969/09/01
N1  - 10.1001/archpedi.1969.02100040522020
JO  - American Journal of Diseases of Children
SP  - 520
EP  - 524
VL  - 118
IS  - 3
N2  - MASSIVE spasms, hypsarhythmia, and developmental retardation comprise a triad of clinical findings occurring only in infancy and early childhood. The triad has been associated with a wide variety of cerebral disorders.1-3 Massive spasms are an age-specific response pattern of the infant's brain. Older children and adults do not exhibit massive spasms or a hypsarhythmic pattern in the electroencephalogram under the same circumstances. Brain malformations have been associated with this triad in less than 10% of pathologically verified cases reported to date. We had an opportunity to study an infant who exhibited massive spasms, hypsarhythmia, and developmental retardation, as well as diabetes insipidus. Fractional pneumoencephalography revealed that she has lobar holoprosencephaly. The case is reported because it is the first such association to be documentedReport of a Case 
    The patient, a female infant, was admitted to the University of Washington Hospital at the age of 5½ months following a
SN  - 0002-922X
M3  - doi: 10.1001/archpedi.1969.02100040522020
UR  - http://dx.doi.org/10.1001/archpedi.1969.02100040522020
ER  -