TY  - JOUR
T1  - PIcture of the month
AU  - Gellis SS, Feingold M, Hansson O
Y1  - 1969/02/01
N1  - 10.1001/archpedi.1969.02100030203015
JO  - American Journal of Diseases of Children
SP  - 201
EP  - 202
VL  - 117
IS  - 2
N2  - Denouement and Discussion 
    Acrodermatitis Enteropathica 
    (Danbolt-Closs Syndrome)Manifestations 
    Acrodermatitis enteropathica usually manifests itself in infancy, shortly after the child has been weaned or has been started on supplementary formula. It is characterized by a symmetrical, erythematous, and vesiculopustular dermatitis localized to the extremities and areas around the body orifices, diarrhea, and alopecia. Additional manifestations include blepharitis, conjunctivitis, corneal opacities, photophobia, stomatitis, glossitis, hoarsness, paronychiae with dystrophy of the nails, failure to thrive, apathy, irritability, and emotional disturbances.Without treatment the disease may be progressive. Short remissions are followed by relapses which are increasingly severe and end fatally. Spontaneous healing has been reported in relation to onset of puberty.Genetics 
    Acrodermatitis enteropathica appears to be inherited as an autosomal recessive trait.Treatment 
    Derivatives of halogen-substituted 8-hydroxy-quinolines (Diodoquin, Entero-Vioform, or Sterosan) are the drugs of choice. Initially a high dosage is often needed for effective treatment, but it is important to determine
SN  - 0002-922X
M3  - doi: 10.1001/archpedi.1969.02100030203015
UR  - http://dx.doi.org/10.1001/archpedi.1969.02100030203015
ER  -