TY  - JOUR
T1  - SAfety of polyethylene glycol 3350 for the treatment of chronic constipation in children
AU  - Pashankar DS, Loening-Baucke V, Bishop WP
Y1  - 2003/07/01
N1  - 10.1001/archpedi.157.7.661
JO  - Archives of Pediatrics & Adolescent Medicine
SP  - 661
EP  - 664
VL  - 157
IS  - 7
N2  - Objectives 
    To assess the clinical and biochemical safety profile of long-term polyethylene glycol 3350 (PEG) therapy in children with chronic constipation and to assess pediatric patient acceptance of PEG therapy.Design 
    Prospective observational study.Setting 
    Pediatric clinics at a referral center.Patients 
    Eighty-three children (44 with chronic constipation, 39 with constipation and encopresis) receiving PEG therapy for more than 3 months.Main Outcome Measures 
    Clinical adverse effects related to PEG therapy and acceptance and compliance with PEG therapy. Serum electrolyte levels, osmolality, albumin levels, and liver and renal function test results were measured.Results 
    At the time of evaluation, the mean duration of PEG therapy was 8.7 months, and the mean PEG dose was 0.75 g/kg daily. There were no major clinical adverse effects. All blood test results were normal, except for transient minimal alanine aminotransferase elevation unrelated to therapy in 9 patients. All children preferred PEG to previously used laxatives, and daily compliance was measured as good in 90% of children.Conclusions 
    Long-term PEG therapy is safe and is well accepted by children with chronic constipation with and without encopresis.
SN  - 1072-4710
M3  - doi: 10.1001/archpedi.157.7.661
UR  - http://dx.doi.org/10.1001/archpedi.157.7.661
ER  -