TY  - JOUR
T1  - NEurodevelopmental and perinatal correlates of simple brain metrics in very preterm infants
AU  - Tich S, Anderson PJ, Hunt RW, Lee KJ, Doyle LW, Inder TE
Y1  - 2011/03/01
N1  - 10.1001/archpediatrics.2011.9
JO  - Archives of Pediatrics & Adolescent Medicine
SP  - 216
EP  - 222
VL  - 165
IS  - 3
N2  - Objective 
    To explore perinatal correlates of 3 simple measures of brain size, known as metrics, in very preterm infants at term-equivalent age and their relationship to 2-year neurodevelopmental outcomes.Design 
    Prospective cohort study of preterm infants born at a gestational age of less than 30 weeks or a weight of less than 1250 g between April 1, 2001, and December 31, 2003, and followed up at 2 years of corrected age.Setting 
    The Royal Women's Hospital and the magnetic resonance imaging unit at the Royal Children's Hospital.Patients 
    Two hundred thirty-six preterm infants.Interventions 
    Brain metrics—biparietal, bifrontal, and transverse cerebellar diameters—on magnetic resonance imaging for preterm infants at term-equivalent age and neurodevelopmental assessments at 2 years of corrected age.Main Outcome Measures 
    Mental Development Index and the Psychomotor Development Index of the Bayley Scales of Infant Development–Revised.Results 
    Higher birth weight z score, shorter duration of assisted ventilation, and postmenstrual age at magnetic resonance imaging were independently associated with increases in the 3 brain metrics, and male sex was associated with larger bifrontal and biparietal diameters. Only the biparietal diameter was predictive of cognitive and motor indices after adjustment for perinatal variables and social risk.Conclusion 
    This study provides further evidence of altered brain growth in preterm infants, relating to growth restriction and severity of illness, that in turn relate to neurodevelopmental outcome.
SN  - 1072-4710
M3  - doi: 10.1001/archpediatrics.2011.9
UR  - http://dx.doi.org/10.1001/archpediatrics.2011.9
ER  -