TY  - JOUR
T1  - TRial effect in newly diagnosed pediatric acute lymphoblastic leukemia—reply
AU  - Koschmann C, Thomson B, Hawkins DS
Y1  - 2010/09/01
N1  - 10.1001/archpediatrics.2010.142
JO  - Archives of Pediatrics & Adolescent Medicine
SP  - 882
EP  - 883
VL  - 164
IS  - 9
N2  - 
In reference to the exclusion of critically ill patients from clinical trials, we agree with Drs Arya and Kulkarni that “opinion and perception of patients who do not participate need to be detailed and systematically analyzed.” However, systematic exclusion of critically ill patients from clinical trial participation would be more likely to reduce the outcome for nonparticipants, thereby artificially increasing the clinical trial effect.

SN  - 1072-4710
M3  - doi: 10.1001/archpediatrics.2010.142
UR  - http://dx.doi.org/10.1001/archpediatrics.2010.142
ER  -