TY  - JOUR
T1  - TRial effect in newly diagnosed pediatric acute lymphoblastic leukemia
AU  - Kulkarni K, Arya L
Y1  - 2010/09/01
N1  - 10.1001/archpediatrics.2010.141
JO  - Archives of Pediatrics & Adolescent Medicine
SP  - 882
EP  - 883
VL  - 164
IS  - 9
N2  - 
We read with interest the article by Koschmann and colleagues1 describing the lack of trial effect in patients with newly diagnosed acute lymphoblastic leukemia (ALL). However, we have some reservations regarding the conclusions and its potential impact as described. A recent article from Texas confirms that there is a wide variation in the percentage of patients enrolled in cancer clinical trials in different centers owing to variations in ethnicity, geography, health care services, and vulnerable population subgroups.2 It is likely that the percentage of patients accrued on a trial could vary widely among different centers owing to available trials and inclusion criteria that could impact outcome.2 A recent study describes the effect of the center where the cancer was treated on outcome of adolescent cancer patients and underscores the importance of Children's Oncology Group cooperative studies.3

SN  - 1072-4710
M3  - doi: 10.1001/archpediatrics.2010.141
UR  - http://dx.doi.org/10.1001/archpediatrics.2010.141
ER  -