TY  - JOUR
T1  - STill wary of rectal acetaminophen—reply
AU  - Goldstein LH, Berlin M, Kozer E, Berkovitch M
Y1  - 2009/05/04
N1  - 10.1001/archpediatrics.2009.82
JO  - Archives of Pediatrics & Adolescent Medicine
SP  - 491
EP  - 492
VL  - 163
IS  - 5
N2  - 
We thank Drs Ousterhoudt and Henretig for their comments. The American Academy of Pediatrics' recommendation to refrain from rectal acetaminophen was based on pharmacokinetic studies showing great variation of peak levels of acetaminophen administered rectally, often not achieving therapeutic levels, with longer time to peak concentrations.1 Our meta-analysis showed that pharmacodynamic variables, such as temperature reduction, were similar with rectal and oral administration.2

SN  - 1072-4710
M3  - doi: 10.1001/archpediatrics.2009.82
UR  - http://dx.doi.org/10.1001/archpediatrics.2009.82
ER  -