TY  - JOUR
T1  - PEdiatric acetaminophen poisoning
AU  - Isbister G, Whyte I, Dawson A
Y1  - 2001/03/01
N1  - 10.1001/archpedi.155.3.417
JO  - Archives of Pediatrics & Adolescent Medicine
SP  - 417
EP  - 418
VL  - 155
IS  - 3
N2  - 
Alander et al1 do not clearly distinguish between adolescents and young children. They stratify overdoses based on whether the overdose was intentional, accidental, or with therapeutic intent. This merely confirms that intentional overdoses occurred in adolescents aged 11 to 17 years and accidental overdoses occurred between the ages of 2 months and 13 years. The spread of ages in the latter group is not shown, but we suspect that it is mainly children younger than 6 years. This method of stratification introduces age as a confounding factor in the analysis. Age is known to be a significant risk factor for hepatocellular injury in acetaminophen poisoning.2- 3 A more applicable approach would be to look at young children (<6 years old) and adolescents (>10-12 years old) separately. Overdoses in children between the ages of 6 and 10 years are very uncommon.

SN  - 1072-4710
M3  - doi: 10.1001/archpedi.155.3.417
UR  - http://dx.doi.org/10.1001/archpedi.155.3.417
ER  -