TY  - JOUR
T1  - PRioritization of comparative effectiveness research topics in hospital pediatrics
AU  - Keren R, Luan X, Localio R, et al
Y1  - 2012/12/01
N1  - 10.1001/archpediatrics.2012.1266
JO  - Archives of Pediatrics & Adolescent Medicine
SP  - 1155
EP  - 1164
VL  - 166
IS  - 12
N2  - Objective 
                  To use information about prevalence, cost, and variation in resource utilization to prioritize comparative effectiveness research topics in hospital pediatrics.Design 
                  Retrospective analysis of administrative and billing data for hospital encounters.Setting 
                  Thirty-eight freestanding US children's hospitals from January 1, 2004, through December 31, 2009.Participants 
                  Children hospitalized with conditions that accounted for either 80% of all encounters or 80% of all charges.Main Outcome Measures 
                  Condition-specific prevalence, total standardized cost, and interhospital variation in mean standardized cost per encounter, measured in 2 ways: (1) intraclass correlation coefficient, which represents the fraction of total variation in standardized costs per encounter due to variation between hospitals; and (2) number of outlier hospitals, defined as having more than 30% of encounters with standardized costs in either the lowest or highest quintile across all encounters.Results 
                  Among 495 conditions accounting for 80% of all charges, the 10 most expensive conditions accounted for 36% of all standardized costs. Among the 50 most prevalent and 50 most costly conditions (77 in total), 26 had intraclass correlation coefficients higher than 0.10 and 5 had intraclass correlation coefficients higher than 0.30. For 10 conditions, more than half of the hospitals met outlier hospital criteria. Surgical procedures for hypertrophy of tonsils and adenoids, otitis media, and acute appendicitis without peritonitis were high cost, were high prevalence, and displayed significant variation in interhospital cost per encounter.Conclusions 
                  Detailed administrative and billing data can be used to standardize hospital costs and identify high-priority conditions for comparative effectiveness research—those that are high cost, are high prevalence, and demonstrate high variation in resource utilization.
SN  - 1072-4710
M3  - doi: 10.1001/archpediatrics.2012.1266
UR  - http://dx.doi.org/10.1001/archpediatrics.2012.1266
ER  -