TY  - JOUR
T1  - Effect of micronutrient sprinkles on reducing anemia: A cluster-randomized effectiveness trial
AU  - Jack SJ, Ou K, Chea M, et al
Y1  - 2012/09/01
N1  - 10.1001/archpediatrics.2012.1003
JO  - Archives of Pediatrics & Adolescent Medicine
SP  - 842
EP  - 850
VL  - 166
IS  - 9
N2  - Objective 
                  To evaluate the effectiveness of Sprinkles alongside infant and young child feeding (IYCF) education compared with IYCF education alone on anemia, deficiencies in iron, vitamin A, and zinc, and growth in Cambodian infants.Design 
                  Cluster-randomized effectiveness study.Setting 
                  Cambodian rural health district.Participants 
                  Among 3112 infants aged 6 months, a random subsample (n = 1350) was surveyed at baseline and 6-month intervals to age 24 months.Intervention 
                  Daily micronutrient Sprinkles alongside IYCF education vs IYCF education alone for 6 months from ages 6 to 11 months.Main Outcome Measures 
                  Prevalence of anemia; iron, vitamin A, and zinc deficiencies; and growth via biomarkers and anthropometry.Results 
                  Anemia prevalence (hemoglobin level <11.0 g/dL [to convert to grams per liter, multiply by 10.0]) was reduced in the intervention arm compared with the control arm by 20.6% at 12 months (95% CI, 9.4-30.2; P = .001), and the prevalence of moderate anemia (hemoglobin level <10.0 g/dL) was reduced by 27.1% (95% CI, 21.0-31.8; P < .001). At 12 and 18 months, iron deficiency prevalence was reduced by 23.5% (95% CI, 15.6-29.1; P < .001) and 11.6% (95% CI, 2.6-17.9; P = .02), respectively. The mean serum zinc concentration was increased at 12 months (2.88 μg/dL [to convert to micromoles per liter, multiply by 0.153]; 95% CI, 0.26-5.42; P = .03). There was no statistically significant difference in the prevalence of zinc and vitamin A deficiencies or in growth at any time.Conclusions 
                  Sprinkles reduced anemia and iron deficiency and increased the mean serum zinc concentration in Cambodian infants. Anemia and zinc effects did not persist beyond the intervention period.Trial Registration 
                  anzctr.org.au Identifier: ACTRN12608000069358
SN  - 1072-4710
M3  - doi: 10.1001/archpediatrics.2012.1003
UR  - http://dx.doi.org/10.1001/archpediatrics.2012.1003
ER  -