TY  - JOUR
T1  - Hypothermia for neonatal hypoxic ischemic encephalopathy: An updated systematic review and meta-analysis
AU  - Tagin MA, Woolcott CG, Vincer MJ, Whyte RK, Stinson DA
Y1  - 2012/06/01
N1  - 10.1001/archpediatrics.2011.1772
JO  - Archives of Pediatrics & Adolescent Medicine
SP  - 558
EP  - 566
VL  - 166
IS  - 6
N2  - Objective 
                  To establish the evidence of therapeutic hypothermia for newborns with hypoxic ischemic encephalopathy (HIE).Data Sources 
                  Cochrane Central Register of Controlled Trials, Oxford Database of Perinatal Trials, MEDLINE, EMBASE, and previous reviews.Study Selection 
                  Randomized controlled trials that compared therapeutic hypothermia to normothermia for newborns with HIE.Intervention 
                  Therapeutic hypothermia.Main Outcome Measures 
                  Death or major neurodevelopmental disability at 18 months.Results 
                  Seven trials including 1214 newborns were identified. Therapeutic hypothermia resulted in a reduction in the risk of death or major neurodevelopmental disability (risk ratio [RR], 0.76; 95% CI, 0.69-0.84) and increase in the rate of survival with normal neurological function (1.63; 1.36-1.95) at age 18 months. Hypothermia reduced the risk of death or major neurodevelopmental disability at age 18 months in newborns with moderate HIE (RR, 0.67; 95% CI, 0.56-0.81) and in newborns with severe HIE (0.83; 0.74-0.92). Both total body cooling and selective head cooling resulted in reduction in the risk of death or major neurodevelopmental disability (RR, 0.75; 95% CI, 0.66-0.85 and 0.77; 0.65-0.93, respectively).Conclusion 
                  Hypothermia improves survival and neurodevelopment in newborns with moderate to severe HIE. Total body cooling and selective head cooling are effective methods in treating newborns with HIE. Clinicians should consider offering therapeutic hypothermia as part of routine clinical care to these newborns.
SN  - 1072-4710
M3  - doi: 10.1001/archpediatrics.2011.1772
UR  - http://dx.doi.org/10.1001/archpediatrics.2011.1772
ER  -