RT Journal
A1 Allin M, Nosarti C, Narberhaus A, et al
T1 GRowth of the corpus callosum in adolescents born preterm
JF Archives of Pediatrics & Adolescent Medicine
JO Archives of Pediatrics & Adolescent Medicine
YR 2007
FD December 1
VO 161
IS 12
SP 1183
OP 1189
DO 10.1001/archpedi.161.12.1183
UL http://dx.doi.org/10.1001/archpedi.161.12.1183
AB Objective 
    To examine the growth of the corpus callosum between adolescence and early adulthood in individuals who were born before 33 weeks' gestation (very preterm [VPT]) and its relation to neuropsychological function.Design 
    A longitudinal cohort study of VPT individuals born between January 4, 1982, and December 29, 1984, and a term-born comparison group.Setting 
    A long-term follow-up study into perinatal predictors of outcome after preterm birth at University College Hospital, London.Participants 
    A total of 72 VPT and 34 term-born individuals were assessed in adolescence (aged 15 years) and in early adulthood (aged 19 years). Adult assessments took place between June 6, 2002, and October 23, 2004.Main Exposure 
    Birth before 33 weeks' gestation.Outcome Measure 
    The cross-sectional area of 4 segments of the corpus callosum, measured on the midsagittal slice of high-resolution structural magnetic resonance images in adolescence and young adulthood.Results 
    Total corpus callosum size increased in term and VPT groups, but growth was much greater in the VPT group (13.4% in the VPT group vs 3.3% in the term group). There were significant associations between adult performance IQ and growth of anterior (P = .001), midposterior (P = .009), and posterior (P = .009) segments in the VPT group.Conclusions 
    The corpus callosum grows dramatically in VPT adolescents, and this growth is associated with neuropsychological outcome. This may represent a delay of a normal maturational process in VPT individuals.