RT Journal A1 Tarini BA T1 The current revolution in newborn screening: New technology, old controversies JF Archives of Pediatrics & Adolescent Medicine JO Archives of Pediatrics & Adolescent Medicine YR 2007 FD August 1 VO 161 IS 8 SP 767 OP 772 DO 10.1001/archpedi.161.8.767 UL http://dx.doi.org/10.1001/archpedi.161.8.767 AB Newborn screening has provided a model of a successful public health screening program for the past 40 years. However, the history of newborn screening is not without controversy. Many of these controversies have been rekindled with the introduction of tandem mass spectrometry, a technology that has greatly increased our ability to detect potential disease in asymptomatic newborns. This review highlights the challenges raised by this and future technological advances as we strive to maintain the success of newborn screening in the 21st century.