RT Journal
A1 Koo WK, Succop P, Hambidge K
T1 SErum alkaline phosphatase and serum zinc concentrations in preterm infants with rickets and fractures
JF American Journal of Diseases of Children
JO American Journal of Diseases of Children
YR 1989
FD November 1
VO 143
IS 11
SP 1342
OP 1345
DO 10.1001/archpedi.1989.02150230100032
UL http://dx.doi.org/10.1001/archpedi.1989.02150230100032
AB • This study aimed to determine the longitudinal changes in serum zinc concentrations and the relationship between serum alkaline phosphatase (AP) activity and serum zinc concentrations in small preterm infants. The total serum AP and serum zinc concentrations were determined serially at 3,6, 9, and 12 months in 72 infants with mean (±SEM) birth weights of 1000±29 g and gestational ages of 28.6 ± 0.3 weeks. Twenty-four of 72 infants had radiographic evidence of rickets and/or fractures (R/F). In infants with R/F, group mean (±SEM) serum AP (371 ±42 U/L) and serum zinc (12.5±1.0 μmol/L) concentrations were significantly higher at 3 months compared with infants in the non-R/F group (193±12 U/L and 9.6±0.3μmol/L, respectively). During the study, the serum AP concentrations decreased, and the serum zinc concentrations increased; both stabilized after 6 months. The serum AP concentrations were not related to the serum zinc concentrations. We speculate that in preterm infants, an increased bone turnover and a release of tissue (bone) zinc may contribute to the higher group mean serum AP and serum zinc concentrations at the time of diagnoses in infants with R/F compared with those infants without R/F.(AJDC. 1989;143:1342-1345)