RT Journal
A1 Balfour HH, Jr, Englund JA
T1 ANtiviral drugs in pediatrics
JF American Journal of Diseases of Children
JO American Journal of Diseases of Children
YR 1989
FD November 1
VO 143
IS 11
SP 1307
OP 1316
DO 10.1001/archpedi.1989.02150230065025
UL http://dx.doi.org/10.1001/archpedi.1989.02150230065025
AB • Pediatricians are made familiar with antiviral drugs and are provided with specific recommendations for treatment of viral diseases. The antiviral drugs in clinical use today are discussed in terms of their doses, routes of administration, mechanisms of action, established and potential efficacies, and toxicities. These drugs include acyclovir, amantadine, trisodium phosphonoformate, ganciclovir, ribavirin, rimantadine, vidarabine, and zidovudine. Biologic response modifiers, such as interferons, are mentioned briefly in their historical context. Future trends in antiviral therapy are anticipated with mention of the most promising candidate compounds currently in preclinical trials.(AJDC. 1989;143:1307-1316)