RT Journal
A1 Shinzawa T, Mura T, Tsunei M, Shiraki K
T1 VItamin k absorption capacity and its association with vitamin k deficiency
JF American Journal of Diseases of Children
JO American Journal of Diseases of Children
YR 1989
FD June 1
VO 143
IS 6
SP 686
OP 689
DO 10.1001/archpedi.1989.02150180064022
UL http://dx.doi.org/10.1001/archpedi.1989.02150180064022
AB • We measured plasma vitamin K concentrations in 194 5-day-old infants three hours after administration of a 4-mg dose of vitamin K (menaquinone-4, Kaytwo syrup, Eisai Co Ltd, Tokyo, Japan). We investigated association with other factors contributing to vitamin K deficiency. These plasma vitamin K concentrations varied greatly among the neonates from values below the limit of detection (2 ng/mL) to more than 1000 ng/mL. The vitamin K concentration was associated with nutritive vitamin K deficiency represented by plasma protein induced by vitamin K absence or antagonist-II (PIVKA-II) values. The wide variation in vitamin K absorption is considered to be one of the major causative factors in infantile vitamin K deficiency.(AJDC 1989;143:686-689)