RT Journal A1 Benton G, Thomas RC, Nickerson BG, McQuitty JC, Okikawa J T1 EXperience with a metered-dose inhaler with a spacer in the pediatric emergency department JF American Journal of Diseases of Children JO American Journal of Diseases of Children YR 1989 FD June 1 VO 143 IS 6 SP 678 OP 681 DO 10.1001/archpedi.1989.02150180056020 UL http://dx.doi.org/10.1001/archpedi.1989.02150180056020 AB • Studies of adults suggest that metered-dose inhalers with spacers are as effective as hand-held nebulizers for bronchodilator delivery. We studied 13 children with acute asthma. They received two puffs every 2 minutes from metereddose inhalers with spacers (range, 4 to 14 puffs) titrated until improvement stopped. Peak expiratory flow increased 34% for metered-dose inhalers with spacers after the first 2 puffs and increased 87% for metered-dose inhalers with spacers after dose titration. After titration, respiratory rate decreased by 12%, heart rate increased by 2%, and breath sounds improved in 92% of the patients. We concluded that the metered-dose inhalers with spacers are an effective device for the treatment of asthma in the pediatric emergency department and that the use of metered-dose inhalers with spacers with titration can achieve significant bronchodilation in the treatment of patients with acute asthma.(AJDC. 1989;143:678-681)