RT Journal
A1 ROSENBLOOM AL, KNUTH CL
T1 GRowth response of growth hormone-deficient patients to 0.06 mg/kg compared with 0.10 mg/kg three times per week of biosynthetic growth hormone
JF American Journal of Diseases of Children
JO American Journal of Diseases of Children
YR 1989
FD June 1
VO 143
IS 6
SP 642
OP 643
DO 10.1001/archpedi.1989.02150180020008
UL http://dx.doi.org/10.1001/archpedi.1989.02150180020008
AB Sir.—The optimal dosage of growth hormone (GH) for the treatment of GH deficiency has not been determined. As little as 2.5 U given once weekly can result in catch-up growth.1 Raben2 established a dosage of 2 U three times per week regardless of body size as the standard that was used into the 1980s. In a series of reports the US Collaborative Study Group concluded that a dosage of 0.06 U/kg of body weight three times per week was appropriate. These and other studies were summarized by Frasier3 in a comprehensive review. He developed a log-dose response curve, based on the published data, that had a very shallow slope, indicating a decreasing cost benefit of increasing dosage.The purpose of this study was to compare what had been a relatively high dosage of pituitary extract GH (0.12 U or 0.06 mg/kg three times per week) recommended by one manufacturer