RT Journal
A1 LEUNG AC, ROBSON WM
T1 PArent-child minimal change nephrotic syndrome
JF American Journal of Diseases of Children
JO American Journal of Diseases of Children
YR 1989
FD April 1
VO 143
IS 4
SP 442
OP 443
DO 10.1001/archpedi.1989.02150160064009
UL http://dx.doi.org/10.1001/archpedi.1989.02150160064009
AB Sir.—Choi et al1 reported the occurrence of nephrotic syndrome in a father and daughter. The parent and child developed the nephrotic syndrome at 22 and 8 years of age, respectively. The father had biopsyproved minimal change nephrotic syndrome and his daughter was presumed to have the same lesion, based on her clinical presentation and response to prednisone therapy. Choi et al also cited a report by White2 of another father and daughter with steroid-responsive nephrotic syndrome.We are aware of another occurrence of minimal change nephrotic syndrome in a parent and child. In 1979, Schwartz and Cornfeld3 reported a case of a mother and son who had relapsing steroid-responsive nephrotic syndrome. The mother's brother also developed the nephrotic syndrome. The mother and brother developed the nephrotic syndrome at ages 8 and 12 years, respectively. They both had a renal biopsy specimen demonstrating minimal glomerular changes. The