RT Journal
A1 Sarnaik S, Soorya D, Kim J, Ravindranath YY, Lusher J
T1 PEriodic transfusions for sickle cell anemia and cns infarction
JF American Journal of Diseases of Children
JO American Journal of Diseases of Children
YR 1979
FD December 1
VO 133
IS 12
SP 1254
OP 1257
DO 10.1001/archpedi.1979.02130120046009
UL http://dx.doi.org/10.1001/archpedi.1979.02130120046009
AB • Recurrences of CNS infarction often lead to progressive neurologic disability in sickle cell anemia. To prevent such recurrences, a periodic blood transfusion program was begun in 1969. Currently, 27 patients are on this regimen. Before inclusion in the program, 12 patients had had one to nine CNS recurrences each. Since the program was started, two patients have had transient CNS ischemia. There were no other recurrences and non of the patients have shown progression of neurologic abnormalities. In addition, there was a striking decrease in bacterial infection and pain. We conclude that periodic transfusions are effective in preventing recurrent CNS infarction in sickle cell anemia. The benefits must be weighed against the potentially serious problem of iron overload, as evidenced by moderately elevated serum ferritin values.(Am J Dis Child 133:1254-1257, 1979)