RT Journal
A1 LaFranchi SH
T1 SExual precocity with hypothalamic hypopituitarism
JF American Journal of Diseases of Children
JO American Journal of Diseases of Children
YR 1979
FD July 1
VO 133
IS 7
SP 739
OP 742
DO 10.1001/archpedi.1979.02130070075016
UL http://dx.doi.org/10.1001/archpedi.1979.02130070075016
AB • Two girls, one with septo-optic dysplasia and the other with posttraumatic brain damage, had the unusual combination of human growth hormone, thyrotropin, adrenocorticotrophic hormone, and vasopressin deficiencies that were associated with sexual precocity in one patient and early sexual maturation in the second patient, and of adult follicle-stimulating hormone and luteinizing hormone concentrations. At autopsy, the first patient had optic nerve aplasia, a normal pituitary gland, and some disorganization of myelinated fibers in the hypothalamus. The second patient had a normal thyrotropin and prolactin response to thyrotropin-releasing hormone, plus hyperphagia, deranged thirst mechanism, and temperature instability. These findings suggest that the lesion may be a defective hypothalamic regulation of pituitary hormone secretion. Congenital or traumatic hypothalamic-pituitary lesions may not affect all releasing factors or trophic hormones in a similar fashion.(Am J Dis Child 133:739-742, 1979)