RT Journal
A1 HOCHMAN HI
T1 IDiopathic (pseudoidiopathic?) hypoparathyroidism
JF American Journal of Diseases of Children
JO American Journal of Diseases of Children
YR 1979
FD April 1
VO 133
IS 4
SP 435
OP 436
DO 10.1001/archpedi.1979.02130040089019
UL http://dx.doi.org/10.1001/archpedi.1979.02130040089019
AB A boy with hypoparathyroid manifestations had adequate renal and skeletal responses to injected parathyroid extract but normal serum immunoreactive parathyroid hormone (i = PTH) concentrations. Low urinary cyclic adenosine monophosphate (c-AMP) excretion during hypocalcemia supported the clinical impression of parathyroid insufficiency.Report of a Case.—A 16-year-old, mildly retarded boy had generalized seizures preceded by behavioral change and irritability of four-week duration. History indicated neonatal seizures with transient hypocalcemia and subdural hematoma. Additional convulsive episodes occurred in infancy and at 6 years of age, at which time serum calcium and phosphorus concentrations were normal on two occasions. Anticonvulsant therapy was given until the age of 8 years. His diet was well balanced and contained copious amounts of milk. Family history was unremarkable.Physical examination on admission to the hospital showed a stuporous, tall, obese adolescent with bilateral papilledema and positive Chvostek's and Trousseau's signs. Skeletal or ectodermal signs of pseudohypoparathyroidism