RT Journal
A1 Cussen LJ, MacMahon RA
T1 GErm cells and ova in dysgenetic gonads of a 46-xy female dizygotic twin
JF American Journal of Diseases of Children
JO American Journal of Diseases of Children
YR 1979
FD April 1
VO 133
IS 4
SP 373
OP 375
DO 10.1001/archpedi.1979.02130040027005
UL http://dx.doi.org/10.1001/archpedi.1979.02130040027005
AB • The frequency of germ cell neoplasms in girls with 46-XY gonadal dysgenesis suggests that germ cells may persist in the dysgenetic gonads for many years. A phenotypic female infant with a karyotype of 46-XY in blood, skin, and gonads had a few ova in primordial follicles and numerous germ cells in her dysgenetic gonads at the age of 3 months. At 3 years and 10 months of age her gonads contained no primordial follicle and the only remaining germ cells were in a gonadoblastoma. We propose that germ cells are lost from dysgenetic gonads much more rapidly than from normal gonads, but that the rate of loss in patients with a karyotype of 46-XY may be less than the rate of loss in patients with a karyotype of 45-XO.(Am J Dis Child 133:373-375, 1979)