RT Journal
A1 GRANOFF DM
T1 Possible postinfectious immune arthritis: Haemophilus influenzae type b-reply
JF American Journal of Diseases of Children
JO American Journal of Diseases of Children
YR 1979
FD March 1
VO 133
IS 3
SP 333
OP 333
DO 10.1001/archpedi.1979.02130030108028
UL http://dx.doi.org/10.1001/archpedi.1979.02130030108028
AB In Reply.—We thank Dr Gruninger for his comments. We are aware of the difficulties encountered in ampicillin disc diffusion sensitivity testing.1 Ampicillin minimal inhibitory concentrations of isolates from cases 1 and 3 were determined by dilution testing and confirmed by measurement of β-lactamase. The ampicillin zone size for the isolate from case 2 was reported by the clinical laboratory as greater than 20 mm, but the organism was not available for additional studies.Dr Gruninger's comments concerning the possibility of postinfectious immune arthritis in case 2 are also of interest. To our knowledge, these sequelae have not been reported previously in patients with invasive H influenzae type b infection, despite the frequent occurrence of prolonged antigenemia2,3 and circulating immune complexes.3 Perhaps age is a factor in view of the fact that the allergic complications to which Dr Gruninger refers are seen primarily in older patients with