RT Journal
A1 Nordan UZ, Humbert JR, MacGillivray MH, Fitzpatrick JE
T1 FAnconi's anemia with growth hormone deficiency
JF American Journal of Diseases of Children
JO American Journal of Diseases of Children
YR 1979
FD March 1
VO 133
IS 3
SP 291
OP 293
DO 10.1001/archpedi.1979.02130030067011
UL http://dx.doi.org/10.1001/archpedi.1979.02130030067011
AB • The association of Fanconi's anemia (FA) and growth hormone (GH) deficiency is not commonly reported. These children may have the typical features of the FA syndrome, or may exhibit much variability in clinical and hematological findings. In a single family, members may have FA with or without GH deficiency. The genetic basis for this heterogeneity is unknown. We describe here two siblings with FA, one of whom had dwarfism due to GH deficiency. Combined treatment with GH and androgen (oxymetholone) resulted in strikingly greater acceleration of growth than did the use of GH alone. Pancytopenia was not influenced by hormone therapy.(Am J Dis Child 133:291-293, 1979)