RT Journal
A1 Movassaghi N, Moorhead J, Leikin S
T1 ANtiplatelet antibodies in childhood idiopathic thrombocytopenic purpura
JF American Journal of Diseases of Children
JO American Journal of Diseases of Children
YR 1979
FD March 1
VO 133
IS 3
SP 257
OP 259
DO 10.1001/archpedi.1979.02130030033003
UL http://dx.doi.org/10.1001/archpedi.1979.02130030033003
AB • The serotonin release test using platelets from a panel of donors and autologous platelets after recovery was used to detect platelet antibodies in 42 children with idiopathic thrombocytopenic purpura. The test was done with sera obtained in the thrombocytopenic phase, in partial recovery, and after recovery. The test results for sera from 23 (55%) of 42 patients with thrombocytopenia were positive against platelets from the donors; 14 (61%) of 23 were positive against autologous platelets; and 28 (88%) of 32 were positive against either donor or autologous platelets. Complete recovery occurred in 17 (52%) of 33 patients whose sera had positive tests against the donor platelets at the time of diagnosis. Postrecovery sera from all patients had negative tests against donor platelets, and two (12%) had positive tests against autologous platelets. These results indicate that childhood idiopathic thrombocytopenic purpura is an autoimmune disease caused by platelet antibody that usually disappears with recovery from the thrombocytopenia.(Am J Dis Child 133:257-259, 1979)