RT Journal
A1 Gellis SS, Feingold M
T1 PIcture of the month
JF American Journal of Diseases of Children
JO American Journal of Diseases of Children
YR 1969
FD September 1
VO 118
IS 3
SP 483
OP 484
DO 10.1001/archpedi.1969.02100040485012
UL http://dx.doi.org/10.1001/archpedi.1969.02100040485012
AB Denouement and Discussion 
    Trisomy 13-15 
    (D Trisomy; 47, XX or XY, D1; Patau's Syndrome)Manifestations 
    Patients with this syndrome are usually small for date infants who fail to thrive, and they usually do not survive beyond the first year of life. They have a typical facial appearance which includes a large broad nose, cleft lip and palate, microcephaly, skin defects of the scalp, anophthalmia or microphthalmia, colobomas of the iris, epicanthal folds, corneal opacities, hypertelorism or hypotelorism, malformed and low-set ears, and micrognathia. The hands are held in a characteristic fashion with the fifth finger overlapping the fourth. Polydactyly, syndactyly, "rocker-bottom" feet, hyperconvex nails, single palmar crease, and abnormal dermatoglyphics are frequently present. Also associated with this syndrome are a short neck with accentuated skin folds resembling webbing, congenital heart disease, renal abnormalities, undescended testes, mental and motor retardation, holoprosencephaly, seizures, deafness, hypoplasia of the ribs, umbilical and inguinal hernias,