RT Journal
A1 Urizar RE, Tinglof B, McIntosh R, et al
T1 IMmunosuppressive therapy of proliferative glomerulonephritis in children
JF American Journal of Diseases of Children
JO American Journal of Diseases of Children
YR 1969
FD September 1
VO 118
IS 3
SP 411
OP 425
DO 10.1001/archpedi.1969.02100040413001
UL http://dx.doi.org/10.1001/archpedi.1969.02100040413001
AB THE VARIOUS forms of proliferative glomerulonephritis, with or without the nephrotic syndrome, are difficult therapeutic challenges and with few exceptions lead inexorably to renal failure. Excluded from consideration are patients with acute poststreptococcal glomerulonephritis in whom complete recovery usually occurs without specific therapy2 and a high percentage of patients with the nephrotic syndrome of childhood who respond to adrenocortical steroid management.3 Some patients with severe lupus glomerulonephritis may recover normal renal function and nearlynormal morphology after intensive treatment with corticosteroids,4,5 although the incidence of serious complications remains high.Involvement of immune processes in the pathogenesis of glomerulonephritis is supported by a large body of information collected during the past 50 years.6 The more recent availability of serial renal biopsy specimens and improved morphologic techniques, particularly immunofluorescence and electron microscopy, together with the measurement of serum immunoglobulins, have further emphasized the probable pathogenic role of immune mechanisms