RT Journal
A1 Gellis SS, Feingold M, Hansson O
T1 PIcture of the month
JF American Journal of Diseases of Children
JO American Journal of Diseases of Children
YR 1969
FD February 1
VO 117
IS 2
SP 201
OP 202
DO 10.1001/archpedi.1969.02100030203015
UL http://dx.doi.org/10.1001/archpedi.1969.02100030203015
AB Denouement and Discussion 
    Acrodermatitis Enteropathica 
    (Danbolt-Closs Syndrome)Manifestations 
    Acrodermatitis enteropathica usually manifests itself in infancy, shortly after the child has been weaned or has been started on supplementary formula. It is characterized by a symmetrical, erythematous, and vesiculopustular dermatitis localized to the extremities and areas around the body orifices, diarrhea, and alopecia. Additional manifestations include blepharitis, conjunctivitis, corneal opacities, photophobia, stomatitis, glossitis, hoarsness, paronychiae with dystrophy of the nails, failure to thrive, apathy, irritability, and emotional disturbances.Without treatment the disease may be progressive. Short remissions are followed by relapses which are increasingly severe and end fatally. Spontaneous healing has been reported in relation to onset of puberty.Genetics 
    Acrodermatitis enteropathica appears to be inherited as an autosomal recessive trait.Treatment 
    Derivatives of halogen-substituted 8-hydroxy-quinolines (Diodoquin, Entero-Vioform, or Sterosan) are the drugs of choice. Initially a high dosage is often needed for effective treatment, but it is important to determine