RT Journal
A1 Clow c, Scriver CR, Davies E
T1 REsults of mass screening for hyperaminoacidemias in the newborn infant
JF American Journal of Diseases of Children
JO American Journal of Diseases of Children
YR 1969
FD January 1
VO 117
IS 1
SP 48
OP 53
DO 10.1001/archpedi.1969.02100030050005
UL http://dx.doi.org/10.1001/archpedi.1969.02100030050005
AB OPPORTUNITIES to survey the newborn human infant for the occurrence of a wide variety of aminoacidopathies and to determine "normal" variation in plasma amino acid composition at this age have been rather limited. Most mass screening programs have focused on a single amino acid. The adaptation of simple modified partition chromatographic techniques1,2 to the analysis of amino acids in whole blood or plasma provided the opportunity to perform mass screening for many aminoacidopathies and to evaluate the worth of this endeavor. It was a subject of great interest to Dr. Efron,3 and one which she pioneered with Dr. MacCready and other colleagues until she could work no longer.In this communication we report on a survey of 36,172 infants, in whom a measured volume of plasma was examined by partition chromatography. Our report follows that completed by Dr. Levy4 after Dr. Efron died, in which her survey