RT Journal
A1 FINLEY SC, HARE RS
T1 BRomide space in infants and children
JF A.M.A. Journal of Diseases of Children
JO A.M.A. Journal of Diseases of Children
YR 1959
FD December 1
VO 98
IS 6
SP 749
OP 755
DO 10.1001/archpedi.1959.02070020751010
UL http://dx.doi.org/10.1001/archpedi.1959.02070020751010
AB Introduction 
    It is well established that when bromide is administered to a human or animal subject it exchanges rapidly with nearly all of the body chloride.1-6 For this reason the volume of distribution of bromide is essentially the same as that of chloride, the exception being the cerebrospinal fluid. When bromide volume of distribution is multiplied by the chloride concentration in serum, the quantity of chloride obtained is that which exchanges rapidly with bromide, and may therefore be called "exchangeable chloride," although it is sometimes called "total body chloride" since the values are so nearly the same.6-7Since the volume of distribution of chloride includes the extracellular fluid, connective tissue, skin, erythrocytes, and, to a minor extent, some other cells, the relationship between chloride (or bromide) space and total body mass will depend upon the composition of the body. When a large proportion of the body weight is