RT Journal
A1 Rivara FP
T1 REgistration of clinical trials
JF Archives of Pediatrics & Adolescent Medicine
JO Archives of Pediatrics & Adolescent Medicine
YR 2005
FD July 1
VO 159
IS 7
SP 685
OP 685
DO 10.1001/archpedi.159.7.685
UL http://dx.doi.org/10.1001/archpedi.159.7.685
AB 
The ICMJE has taken this position because currently there is no requirement that trial results be made public. Pharmaceutical companies, medical device manufacturers, and the developers of clinical procedures or patient interventions may sometimes be tempted to submit for publication clinical trials that report results favorable to products or inventions but conceal trials that report no benefit or adverse effects.2 To the extent that favorable trials are more often submitted, the published medical literature may present a distorted picture of available evidence about treatment. The ICMJE hopes that a trial registry will allow editors, journal reviewers, journal readers, and investigators who systematically review evidence to find out whether all available trial evidence for a particular intervention has been published.