RT Journal
A1 Mull CC, Scarfone RJ
T1 BRonchiolitis—reply
JF Archives of Pediatrics & Adolescent Medicine
JO Archives of Pediatrics & Adolescent Medicine
YR 2004
FD July 1
VO 158
IS 7
SP 707
OP 707
DO 10.1001/archpedi.158.7.707-b
UL http://dx.doi.org/10.1001/archpedi.158.7.707-b
AB 
Our decision to compare epinephrine with albuterol was based on our clinical observation that a substantial proportion of infants moderately ill with bronchiolitis responds favorably to bronchodilators. This proportion was appreciated to be high enough that we felt it unjustified to deny therapy to a placebo group. In light of the Menon et al1 study, our goal was to clarify the role of epinephrine in comparison with albuterol in the treatment of such infants. At the time that this study was conducted, the standard of care for these patients at our institution included provision of a trial of nebulized albuterol. As such, the hospital's institutional review board would not have approved a placebo study.