RT Journal A1 Sherman PM, Zlotkin SH T1 DEvelopment of novel medications for use in the treatment of obesity in children will be directed by delineating controls of energy homeostasis JF Archives of Pediatrics & Adolescent Medicine JO Archives of Pediatrics & Adolescent Medicine YR 2003 FD August 1 VO 157 IS 8 SP 721 OP 721 DO 10.1001/archpedi.157.8.721 UL http://dx.doi.org/10.1001/archpedi.157.8.721 AB Future attention must be paid to both the prevention and treatment of childhood obesity. However, as many will know from personal experience, it is not clear what are the most appropriate interventions. Even very small discrepancies in energy intake will result, in the long run, in excess weight gain.1 Reduced intake, increased exercise, and the changes in lifestyle that are advocated to achieve these goals are difficult—if not impossible—for many to maintain for protracted periods of time.