RT Journal
A1 Collett BR, Speltz ML, Cloonan Y, Leroux BG, Kelly JP, Werler MM
T1 NEurodevelopmental outcomes in children with hemifacial microsomia
JF Archives of Pediatrics & Adolescent Medicine
JO Archives of Pediatrics & Adolescent Medicine
YR 2011
FD February 1
VO 165
IS 2
SP 134
OP 140
DO 10.1001/archpediatrics.2010.271
UL http://dx.doi.org/10.1001/archpediatrics.2010.271
AB Objective 
    To determine whether preadolescent children with hemifacial microsomia (HFM) have higher risk of neurodevelopmental delays than unaffected control individuals.Design 
    Case-control follow-up study of neurodevelopment in children with and without HFM.Setting 
    Case individuals were originally recruited from 26 craniofacial centers across the United States and Canada, and controls were recruited through community pediatricians.Participants 
    One hundred thirty-six children with HFM (cases) and 568 unaffected children (controls).Main Exposure 
    History of HFM.Main Outcome Measures 
    The Peabody Picture Vocabulary Test–Third Edition, the Beery-Buktenica Developmental Test of Visual Motor Integration–Fifth Edition, and the Academic Competence scales from the Child Behavior Checklist and the Teacher Report Form.Results 
    Children with HFM scored lower than controls on all measures (effect size = −0.27 to −0.45; P < .001 to P = .008). Compared with controls, cases were 2 to 3 times as likely to score in the at-risk range. Relative to controls, outcomes were worse for male cases and those whose mothers were 25 years or younger at the time of their birth. Cases with HFM plus other malformations had poorer outcomes, as did cases with hearing, vision, or speech impairments.Conclusions 
    This is the first study, to our knowledge, to show that children with HFM have poorer neurodevelopmental outcomes than unaffected children, but further study using more detailed assessments is indicated. Clinically, the findings suggest that early neurodevelopmental screening is warranted for all children with HFM.